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18 Not surprisingly, TMA formation inhibitors targeting microbial TMA lyase have been developed, reducing TMAO levels in mouse models and reversing atherosclerosis, which may also become a means of treatment for AF

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9 While it is debated whether elevated TMAO levels represent a cause or a consequence of CVD, 2-4 elevated TMAO levels are currently an important risk factor associated with increased CVD risk, adverse cardiovascular events, and cardiovascular death

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