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If you are taking supplements without a documented deficiencyperhaps for general wellness or energydiscuss with your GP whether continuation is medically justified

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Clarifying the Molecular Basis of Cobalamin (Vitamin B12) Neurotrophism

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Another molecular approach is based on the expression of the dominant-negative IGF-1R receptor (dnIGF-1R), which makes a complex with a wild-type half receptor and can bind a ligand but lacks kinase activity, thus blocking the function of endogenous IGF-1R