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Endoneurial microangiopathy, characterized by capillary abnormalities, occurs early in DPN and correlates with clinical, neurophysiological, and morphological abnormalities

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ROS produced by CIH activate chemoreflex mechanisms, thereby enhancing the chemosensitivity and responsiveness of the CB to hypoxic conditions and stimulating sympathetic nervous system activity (105, 106)

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Regulatory agencies hold the key to improving Cochrane Reviews of drugs [editorial]

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