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Previous USP guidelines official from 2014 to November 2023 did not have any stated preservative requirement for BUD extension, instead dividing aqueous dosage forms into categories based on oral vs non-oral (topical, mucosal etc.) routes of administration

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61 One of the most well-known studies of TPE, the double-blind placebo-controlled AD management by albumin replacement (AMBAR) trial, hypothesized that withdrawing plasma might flush A plaque from the brain into the plasma where it could be removed, thereby reducing AD signs and symptoms

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