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SIRT6 in senescence and aging-related cardiovascular diseases

ERGO directly inhibits histamine-metabolizing enzyme and promotes polarization of anti-inflammatory microglia We hypothesized that ERGO may change microglial phenotype by inhibiting HNMT because ERGO potentially inhibits the enzymatic activity of histamine N-methyltransferase (HNMT) although detailed inhibition analysis has not yet been examined [42]

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Furthermore, the age-related decline in SIRT6 expression was suppressed in the ERGO group (Fig