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In some rodent models, HDAC inhibitors treatment has produced significant anti-aging and healthy lifespan effects, but direct effects on longevity have not been demonstrated

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doi: 10.1038/s43018-022-00424-8

PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity

In a Phase II double-masked trial, there was no difference in BCVA at 84 weeks in patients with chronic LHON treated with topical elamipretide, a mitochondria-targeting peptide that promotes increased ATP production and decreased ROS production [54]

However, it is important to appreciate that endogenous and exogenous antioxidants work as a team to optimize protection against radical-mediated cellular damage