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A group of Croatian patients with dwarfism and multiple hormone deficiencies (GH, TSH, PRL, FSH/LH) related to homozygous PROP1 mutations do not experience diabetes mellitus, early grey hair, or death (40)

While some benefits have been observed in several studies for the various diseases and conditions discussed here, the side effects associated with anti-VEGF or anti-VEGFR-2 therapies can be severe and include heightened risk of arterial thromboembolic events, hypothyroidism, wound healing complications, GI perforations, neutropenia and hematological effects and increased risks for other cardiac adverse events (245, 247249)