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Discontinuation of a concomitantly used cytochrome P450 2D6 inhibitor may result in a decrease in codeine plasma concentration and an increase in active metabolite morphine plasma concentration which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression

Instead, they may support nutrient pathways that are already part of how the body processes fats

74,75 Given that the majority of tissues and organs in diabetic patients are affected by hyperglycemia-induced oxidative stress, using natural products with anti-diabetic and antioxidant abilities may have several positive impacts

To modify antioxidants in therapy, strategies include targeting GPX4 activity, manipulating GSH levels, optimizing exogenous antioxidants, and exploiting Nuclear factor erythroid 2related factor 2 (NRF2) pathways [254]

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