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Thus, Graf et al

16 Combining therapies with complementary but distinct mechanisms of action may lead to greater weight loss and improvements in associated risk factors compared with individual medications

This process leads to the accumulation of cholesterol in the endoplasmic reticulum and increased production of 24-hydroxycholesterol (24HC)

Unfortunately, the preclinical development of antibodies and most biologics suffers from the lack of predictive in vivo models

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