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Furthermore, cytokines from Th2 cells can weaken BBB integrity by affecting tight junction proteins, thereby facilitating immune cell infiltration into brain tissue [317, 320]

130 Thus, high expression levels of MMR components may exert a positive influence both on the propensity of chemotherapy-naive tumors to relapse (perhaps because MMR limits the accumulation of additional genetic alterations) and on the probability that neoplasms exposed to CDDP become chemoresistant