mitochondrial damage glutathione dysfunction and oxidative stress in metabolic disorders - A Step towards mitochondria based therapeutic strategies Glutathione (GSH) and antioxidant enzymes,

& Dyess, G

doi: 10.1155/2016/9348651

2014;9:e109114

Transforming growth factor- (TGF-) is known to promote fibrosis and contribute to POF (Persani et al., 2011), and collagen content and fibroblast proliferation are significantly reduced, which is related to AMPK-mediated suppression of TGF- production after metformin administration (McCloskey et al., 2020)

MnO 2 NPs with mesoporous shell have been widely proved to show the ability to load chemotherapy drugs for efficient targeted drug delivery with controlled drug release behaviors (21, 22)

Some nanformulations are already making efforts in this regard, for example, targeted nanotherapy has attracted a great deal of attention and effort from scientists, and has made extensive progress in basic research [35, 566,567,568]