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Time of day Twice-daily dosing (most common): Morning: 30-60 minutes before breakfast Evening: 30-60 minutes before dinner OR before bed Consistent timing each day helps Once-daily dosing: Morning preferred (on empty stomach) Or before bed for healing during sleep Choose what fits your schedule Does timing matter much

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For individuals where pigmentation has a metabolic or oxidative origin (rather than a purely superficial one), this makes a meaningful difference
[DOI] [PubMed] [Google Scholar] 125.van der Pol A., Gil A., Tromp J., Sillj H.H.W., van Veldhuisen D.J., Voors A.A., Hoendermis E.S., Grote Beverborg N., Schouten E.M., de Boer R.A., et al
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R--lipoic acid