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It stimulates insulin release in a glucose-dependent manner, suppresses glucagon, slows gastric emptying, and signals satiety to the brain
In mitochondria, pyruvate is decarboxylated by pyruvate dehydrogenase kinase 1 (PDK1) to generate acetyl coenzyme A (76)
In contrast, IGF binding proteins (IGFBPs) capture free IGF-1 and inhibits IGF-1 binding to IGF-1R
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129, doi:10.1039/9781847559531-00001, ISBN 978-1-84755-899-2, retrieved 2025-06-18 Journal of the American Chemical Society
