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Without adequate B12 levels, red blood cell formation is impaired, leading to the emergence of larger, irregularly shaped cells called megaloblasts

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In effect, in order to exert its anti-mitochondrial dysfunction properties facilitating the synthesis of proteins, orotic acid has to be saltified with an organic cation eg, carnitine, for its total solubilization and subsequent ease of absorption

Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to GSTo1