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10.1074/jbc.m310994200 J
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This is why a gradual dose titration schedule is standard practice
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Subsequently, to reduce the dosage intervals and enhance the bio availability, the drug releasing pattern of Glibenclamide was modified by forming mucoadhesive beads using sodium alignate and okra gum for drug entrapment, allowing sustained release for up to 8 h in the body [2, 78]
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