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doi: 10.1172/JCI9842

Some of these have already been discussed, including the need to follow a clinical hierarchy of diagnoses, the variability of the symptoms and impacts of endometriosis, concerns about laparoscopy, managing trials of treatment (as sanctioned in the National Institute for Health and Care Excellence [NICE] guidance), 17 and supporting women who, at points in their care journey do not want referral (for example, if their symptoms are well controlled in primary care)

Binding affinity predictions suggested that E1 peptide has a comparable binding affinity with ES2r2, albeit in vitro analysis showed that E1 had much less activity than ES2r2

A lower Firmicutes/Bacteroidetes ratio (142), reduced counts of Lactobacillaceae (143), and altered abundance of several genera have been reported (144) including Eggerthella , Klebsiella , Flavonifractor , Lachnospiraceae (145, 146), Prevotella , Eubacterium, and Rhodococcus were significantly enriched, whereas Pseudobutyrivibrio and Dialister were decreased in SLE patients (147)