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[5] It proceeds via acid-base catalysis through a three-step mechanism, involving two strictly conserved amino acid residues, a lysine (Lys) and a glutamate (Glu)

Dual-drug codelivery nanosystems Since the approval of nanotherapeutics that are commercially available, such as Abraxane (nab-paclitaxel), Doxil (liposomal doxorubicin), Onivyde (liposomal irinotecan), and Vyxeos (daunorubicin and cytarabine liposome), there has been a growing interest in nanocarrier approaches to deliver therapeutic agents

Chapter 33

While some trials have demonstrated the safety and feasibility of these therapies, many face challenges relating to therapeutic efficacy, pharmacokinetics, and long-term safety

, Nugent K., and Raj R

This is accompanied by a shift in macrophage populations, with a higher number of pro-inflammatory M1 macrophages and reduced anti-inflammatory M2 macrophages in Hunner lesions