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However, for high cluster copy or high levels of expression, there seem to be limitations somewhere else in the metabolism, which cause a shift to a more complex regulation, as exemplified in the metabolic engineering optimization of -lactam production [98, 99]

Note: Methods of preparation: Solvents allowed for the methods of preparation, Non-Standardized Extracts Dry extract and Non-Standardized Ethanolic Extracts Dry extract as part of this monograph are ethanol and/or water only, unless otherwise specified

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cocaine, for example, is used as a local anesthetic (Chapter 2), and amphetamines and methylphenidate are used in low doses to treat attention deficit hyperactivity disorder and in higher doses to treat narcolepsy (Chapter 12)

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