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Bempedoic acid, a notable ACLY inhibitor, effectively reduces lipid levels and received FDA approval in 2020 as a cholesterol-lowering drug

May help support a healthy inflammatory response
Luo C, Wang Z, Liao J et al (2025) Luteolin ameliorates kainic acid-induced seizure by modulating GADD45B and reducing oxidative stress in hippocampal neurons

Amaral L., Martins M., CrteReal M., et al., The Neurotoxicity of Pesticides: Implications for Parkinson's Disease, Chemosphere 377 (2025): 144348

Phytochemical and pharmacological profiles of three fagopyrum buckwheats

The environment can also alter DNA methylation or histone modifications, regulating the expression of inflammatory genes and enhancing the innate immune response ( Figure 2 )
