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E.CirilliI.et al (2020)

During iron scarcity, the IRE-IRP system also downregulates proteins associated with iron usage [37], including the haem synthesis protein, 5-aminolevulinic acid synthase (ALAS)-2 [38], and the tricarboxylic acid (TCA) cycle enzyme, mitochondrial aconitase 2 (ACO2), which requires a [2Fe-2S] cluster for catalysis [39]

doi: 10.1093/ajcn/43.5.787

It also influences mitochondrial biogenesis by upregulating sirtuins, particularly SIRT1 and SIRT3, which play roles in deacetylating mitochondrial proteins and enhancing complex I activity [1,60]

Rather than viewing persistent symptoms as inevitable, this growing body of evidence underscores the importance of a proactive and individualised management strategy for HT

Quality of the peptide and quality of the oversight are inseparable
