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Curcumin, a natural polyphenol derived from Curcuma longa, offers a promising approach to inhibit NLRP3-induced inflammation owing to its multi-targeted actions and excellent safety profile

Furthermore, we discuss the mechanistic crosstalk by which ferroptosis remodels the immunosuppressive landscape, specifically affecting the polarization of tumor-associated macrophages (TAMs) and the stability of regulatory T cells (Tregs)

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