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10.1016/j.jalz.2013.05.233 167 RizigM.Bandres-CigaS.MakariousM

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[14] The lone pair of electrons moves down kicking off the lone pairs that were making the double bond

Figure 4 Figure 5 Catalytic activity of GR and response to abiotic stress Glutathione reductase undergoes redox interconversion reactions (GSSG to GSH and GSH to GSSG) which depend on the availability of the required substrate (Rao and Reddy, 2008)

Targeting extracellular ROS signaling of tumor cells

Research highlights that these mitochondrial changes are driven by hyperglycemia-induced ROS, leading to bioenergetic deficits in neuronal cells