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Point mutations within the PLC 2 PH domain decreased Rac1-dependent activation, but had little to no effect on G -mediated activation (Jezyk et al., 2006)

doi: 10.1007/s10545-006-0199-x 41
Individuals with hypothyroidism : May interfere with thyroid hormone action

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This observation is consistent with increased production rate of apoC1 in hypertriglyceridemic individuals [3], although the causal link between both phenomena was not investigated in this clinical study