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International Journal of Food Sciences and Nutrition, 2009;60 Suppl 5:71-6

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First, NASH therapy should aim to eliminate the factors contributing to disease development and progression, reduce hepatocyte damage, prevent steatohepatitis progression to fibrosis and cirrhosis, improve tissue sensitivity to insulin, and manage NASH-related metabolic disorders [4, 5, 26, 27]

These results with aged beagle dogs, whose brains, as noted above, have A42 of identical amino acid sequence as A42 in human brains and therefore the observations are likely applicable to humans, support the notion that translational intervention in MCI and AD individuals involving these two strategies, i.e., high-antioxidant-containing diets (such as one would experience with a Mediterranean diet) coupled with deliberative efforts to produce new synaptic connections (such as learning a new language, to play a new musical instrument, and/or to solve challenging puzzles) conceivably would decrease the neuropathology and rate of cognitive decline associated with both disorders