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Activation of NLRP3 and its Role in Inflammation The process of assembling and activating NLRP3 is closely regulated by inflammasomes, which are responsible for inflammation and can be activated by a variety of factors such as pathogens, including yeast, bacteria, and viruses, endogenous danger signals like ATP, and particulates such as uric acid crystals, fibrillar amyloid-, and malarial hemozoin, and environmental irritants like silica, asbestos, UVB radiation, and skin irritants