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Terstappen GC, Meyer AH, Bell RD, Zhang W

242 The cycle is exacerbated by hypoxia-inducing gene-activating histone modifications that up-regulate expression of endothelin 1, thus, reducing oxygen delivery to the kidney by vasoconstriction

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We will discuss the key barriers to clinical success for next-generation inflammasome therapeutics, and the tools and strategies that can help overcome them
