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doi: 10.1007/s00253-013-4750-z 73 LiuF.MalaphanW.XingF.YuB

PMID 14279251
Taken together, these studies provide support for the role of EVs in metabolic reprogramming and alteration of the TME to promote tumor growth (Figure 7)

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In addition, mitochondrial swelling also appears to increase with age due to the increased opening of mitochondrial permeability transition pore (mPTP)