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This is largely due to enhanced mitochondrial activity and increased fatty acid oxidation, meaning the body burns more calories even without additional exercise

No human clinical trials have been completed

Further Reading For additional peer-reviewed research, see: NNMT inhibitor preclinical study by Neelakantan et al

Potentially suppressing appetite in some individuals

2017 NNMT knockdown in adipocytes was associated with improved markers of insulin sensitivity and glucose uptake in preclinical in vitro models, linking NNMT to metabolic homeostasis

Despite these points, for studies where efficacy and precise control are paramount, the benefits often outweigh the logistical hurdles