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Indian Journal of Anaesthesia 2003;47(3):17880

Procurement Note Institutional buyers may request a Certificate of Analysis (CoA) and Certificate of Conformance (CoC) for each lot

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Substances That Aggravate RLS Several common substances increase nervous system excitability: Caffeine stimulates dopamine release earlier in the day and worsens nighttime rebound symptoms Alcohol disrupts sleep architecture and increases nighttime awakenings Nicotine increases sensory sensitivity and delays nervous system relaxation Certain medications, including some antidepressants and antihistamines, may also exacerbate RLS and should be reviewed with a healthcare provider

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Reviewing solvent compatibility, pH, handling procedures, and storage conditions often resolves the issue