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The field needs validated, in vivocompatible flux sensors (O 2 , H 2 O 2 , NO/ONOO ) targeted to matrix/IMS, ER lumen, peroxisomes, plasma-membrane microdomains and nucleus, each with built-in specificity controls and reporting standards (matrix, oxygen tension, m, pH) to disambiguate signalling pulses from damage plateaus

( Manganese superoxide dismutase (MnSOD) is an enzyme belonging to SOD, which is located in the mitochondrial matrix and can remove O 2 generated by energy metabolism, while glutathione peroxidase 1 (GPX1) is the most abundant of the four identified GPX isozymes

Shore, G

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Quercetin: a functional dietary flavonoid with potential chemopreventive properties in colorectal cancer