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Chronic pain was historically viewed as a monolithic symptom and managed with opioidcentric models, causing widespread therapeutic failure

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If nausea was the reason for the switch, the built-in pyridoxine provides a layer of protection that plain tirzepatide does not

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But some studies also suggest that sensory neurons promote pathogen infection in the intestinal tract, sensory neurons play an indispensable role in the process of neurogenic inflammation
Moreover, both pro- and anti-ferroptotic roles of HO-1 have been observed depending on cell types and pathological conditions 50
