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The main pathological features of PD are the loss of dopaminergic neurons (DA neurons) in the substantia nigra and the formation of Lewy bodies (LB)
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Deze onderzoeksmodellen stellen wetenschappers in staat om moleculaire mechanismen te onderzoeken die betrokken zijn bij de redoxbalans, intracellulaire signalering en metabole regulatie

This observation is in contrast to what is typically observed in obesity, where there is an increase in M1 macrophages (Thomas and Apovian, 2017)

doi: 10.1038/ncomms9873

It has been shown that intracellular GST levels are increased in pulmonary fibrosis cells from IPF mice models and patients, suggesting that GSTs may play an important role in promoting pulmonary fibrosis formation [149]