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Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations (FELASA) recommendations, and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb

Multiple cohorts and clinical observations indicate a higher tendency to hyperglycemia and increased insulin requirements during the luteal phase, alongside a greater risk of hypoglycemia in the follicular phase if insulin doses are not adjusted [99]

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Others notice no such effect

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