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5) AD AD, the most common neurodegenerative disorder worldwide, is characterized by typical neuropathological features, including extracellular A plaques and intracellular neurofibrillary tangles composed of the hyperphosphorylated Tau-protein [432]

Transfer of nanocarriers across the BBB and biological effects The main goals for BBB-targeted nanocarriers are at least three-fold, namely increase solubility, enhance brain penetration to reach better therapeutic efficiency, and minimize peripheral side-effects

Dynamic mechanical deformation of neurons triggers an acute calcium response and cell injury involving the NmethylDaspartate glutamate receptor

10.1152/ajplung.00188.2016 15 BlakytnyR.JudeE

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