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Innovations in drug delivery systems, such as advanced nanocarriers and novel intrathecal formulations, are actively being explored to overcome the biodistribution and bioavailability barriers specific to the CNS, which are crucial for both biological therapeutics and small molecules (69)

To generate the transgenic plant expressing 35S::PAD2-6myc/pad2-1 ( PAD2 / pad2-1 ), the coding sequence of PAD2 ( AT4G23100 ) was cloned into the binary vector pCAMBIA1300 , and then transformed into pad2-1

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