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10.1007/978-1-4939-9220-1_9 63 KamatA

Clinical human studies confirming these findings are still pending

doi: 10.1186/s13104-019-4540-5

Chronic oxidative stress may exacerbate LD accumulation as a means to regenerate NAD from NADH under conditions of excess energy supply ( Figure 1B ), as observed in cultured mouse hepatocytes in which expression of fatty acid synthase ( FASN ) and sterol response element-binding protein 1c ( SREBF1 ) are induced (133)

The depth of evidence differs sharply, and findings in one population may not translate to others

This phenomenon may therefore play an important role in cryoprotection or radioprotection induced by DMSO 37,38 and can also modify the response of yeast to substances dissolved in DMSO