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Ancient medical documents suggested diseases originated from 'decomposing intestinal material,' but contemporary understanding shows that constipation does not cause all illnesses yet has a substantial effect on both health and well-being

For example, exposure to PM 2.5 led to airway inflammation, collagen deposition, and airway remodeling, which were accompanied by a Treg/Th17 imbalance and a decrease in miR-224 in an asthmatic mouse

If it is paired with pain, diarrhea, or constipation, it may indicate a need for digestive support

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Redox changes, such as an increase in H 2 O 2 , RNA oxidation observed in samples from patients, and mitochondrial dysfunction, that was evidenced as an increase of lipid peroxidation of the subunit of the mitochondrial ATP-synthase, seem to be of utmost importance for the early development of the AD pathology in the EC (Nunomura et al., 2001