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Mice treated with TMAO prior to heart failure (HF) development exhibited worsening pulmonary edema, cardiac enlargement, systolic dysfunction, and myocardial fibrosis compared to placebo-treated mice [66,67]

Similarly, in patients with hypertension and hyperhomocysteinemia (18 males and 7 females, age 4065), reactive hyperemia is improved by 4 weeks oral L-arginine (Reule et al., 2017), administered in a mixture with pycnogenol, which itself activates eNOS (Fitzpatrick et al., 1998)

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In addition, Mn-mediated STING activation plays an important role in the host defense against bacterial infections 135

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