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Chen X, Famurewa AC, Tang J, Olatunde OO, Olatunji OJ

Feb 2023;4(1):e200

Another deleterious mechanism associated with mitochondrial dysfunction is the limitation in ATP production that can cause an energy crisis in neurons (Nicholls, 2013) and calpain-activation are linked to AD (Saito et al., Not only are mitochondria associated with UPS function in regards to ATP production and the generation of ROS, the UPS is also linked to mitochondrial function, as recent studies revealed that the UPS degrades mitochondrial proteins and thus contributes to mitochondrial quality control (Taylor and Rutter, 2011)

Thus, Notch receptors and ligands are key players in processes that promote the malignant potential of tumors (42)

During pathological conditions like diabetes, COPD, and kidney disease, structural modifications of HSA induced by glucose or acrolein can strongly impair its antioxidant properties

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