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Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13

In adults with type 2 diabetes, doses up to 12 mg weekly produced roughly 17% weight loss at 36 weeks alongside ~2.0% HbA1c reductions versus placebo [3]

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The focus was on dialysis patients with end-stage renal disease