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In the current study, methotrexate-induced hepatotoxicity was documented by increased AST, ALT, and bilirubin levels compared with the control

We reasoned that a low level of IDH1 (11.7%) mutation in the patient tumor may easily loss in the later serial transplantation and account for the alteration of IDH status in xenografts

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5e, f and Supplementary Fig

Symptoms may include fatigue, weakness, memory problems, difficulty concentrating, mood changes, numbness or tingling in the hands and feet, and difficulty maintaining balance