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doi: 10.3389/fmed.2024.1335551

The human ACE gene expresses two distinct isoforms, the somatic ACE (sACE) and testicular ACE (tACE) 294

Subsequent studies have extended the functional spectrum of histone lactylation beyond immune regulation to developmental and differentiation contexts, which has been observed in embryonic stem-cell differentiation, endometrial reconstruction, and osteogenic development [86,87,88]

Matthay M

Secondary bile acids, modified by microbial bile salt hydrolases (BSH), function as signaling molecules through receptors such as FXR and TGR5, influencing microbial composition by selectively suppressing pathogens and promoting symbionts like Bacteroides 40,46

To mitigate metabolic and physiological disparities, humanized zebrafish modelssuch as those with knock-in of the human CYP3A4 genecan be generated via CRISPR/Cas9