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Gong L, Tang Y, An R, Lin M, Chen L, Du J
J Cancer Surviv
Important and potentially practice-changing innovations in ADC design, biomarker development and combination therapies are ongoing in preclinical and clinical studies
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The cysteine moiety of GSH can be liberated via -glutamyl cycle in which exported GSH is cleaved sequentially by two exofacial enzymes, namely -glutamyl transpeptidase (GGT) and dipeptidase (DP) to release cysteine which is then imported into the cells 6
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Markowitz et al, 1988
