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Mitochondrial dysfunction leads to a reduction in ATP production and the accumulation of reactive oxygen species (ROS), which can cause tissue hypoxia and oxidative stress, thereby directly stabilizing the HIF-1 protein (inhibiting its ubiquitination and degradation) (34)
Acetyl-L-carnitine as a putative candidate for the treatment of stress-related psychiatric disorders: Novel evidence from a zebrafish model
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Takano, 2015)
Mol Neurobiol 57:30753088
