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PMID 19109662

Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)

PMID: 10791689

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This invaluable substance thus has remarkable liver-related detoxification properties and is responsible for eliminating many 'xenobiotic' (foreign) toxins