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Furthermore, the same nucleosome/CCAN structure can also assemble without CENP-A, that is, on naked DNA (10), or with the H3 nucleosome (13), so the question of how exactly CENP-A specifically recruits CCAN is therefore still open

Those who want a standardized combination in a single reconstitution may prefer the blend

Early In Vivo Efficacy Studies: While safety is a top priority, conducting initial animal studies to assess if the drug has the desired therapeutic effect can be valuable alongside SP studies

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