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Int J Devl Neurosci 47:259265 Derks TGJ, Touw CML, Ribas GS et al (2014) Experimental evidence for protein oxidative damage and altered antioxidant defense in patients with medium-chain acyl-CoA dehydrogenase deficiency

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evaluated the plasma L-carnitine levels of subjects with high levels of TMAO ( n = 2,595) and found that the intake of large amounts of L-carnitine caused cardiovascular disease (CVD) and major adverse cardiac events (MI, stroke, or death)