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Enhanced NRF2 activation and its protective effects against ROS have also been observed in multiple human cancer types, often due to mutations in the KEAP1 gene (Romero et al

10.1016/j.redox.2023.102923 [DOI] [PMC free article] [PubMed] [Google Scholar] 475.Zhang, S

However, straightforward augmentation of oxygen supply in the constructs will not yield a sustainable general solution because high concentrations of oxygen (hyperoxia) can inadvertently lead to ROS overproduction 34 (Fig

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But they have a swollen sore knee, and they have body aches elsewhere, and they have tingling and numbness, and they have confusion, and theyre tired, and other things are going on

Once inside host tissue, many putative virulence genes are upregulated in vivo (18, 19)