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The Phase I detoxification system is composed mainly of cytochrome P450 (CYP450) supergene family of enzymes and is generally the first line of enzymatic defense against foreign compounds to inactivate them

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Chronic activation of inflammasome signaling in microglia and astrocytes, characterized by the upregulation of NLRP3 and NF-B, has been linked to the establishment of a neuroinflammatory environment, leading to synaptic loss and exacerbating tau pathology

Here, we investigated the bioenergetic and proteomic changes in ALS mouse motor neurons and patients skin fibroblasts