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A set of standard quality metrics for the raw dataset was determined using third-party (FastQC v0.11.9) and in-house (FastQA v 3.1.25) QC tools

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There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

10.1038/nm1632 202 PavaM

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DMDD treatment inhibited high glucose-induced expression of Hif3a, cleaved parp, Bad, Bax, caspase 9, cleaved caspase 9 (37 kDa), and cleaved caspase 3 in HT22 cells (Figure 8C)